Multi/minicore myopathy


Multi/minicore myopathy
SpecialtyCardiology

Multi/minicore myopathy is a congenital myopathy usually caused by mutations in either the SEPN1 and RYR1 genes. It is chartacterised the presence of multifocal, well-circumscribed areas with reduction of oxidative staining and low myofibrillar ATPase on muscle biopsy. It is also known as Minicore myopathy, Multicore myopathy, Multiminicore myopathy, Minicore myopathy with external ophthalmoplegia, Multicore myopathy with external ophthalmoplegia and Multiminicore disease with external ophthalmoplegia.

Contents

Presentation


There are four types of minicore myopathy

Classical type (75% cases)

The usual presentation is in infancy or childhood with hypotonia or proximal weakness. This weakness tends to affect the shoulder girdle and the inner thigh.

The other main features are

A high arched or cleft palate may be present.

Later developing features include a progressive scoliosis and respiratory impairment.

Ophthalmoplegic form (5-10% cases)

This typically presents with weakness of abduction and upward gaze. Ptosis may occur. There is also weakness of the proximal limb muscles.

Progressive form with hand involvement (10% cases)

The type presents with progressive hand weakness and hypermobility. Hip girdle weakness may be present and exercise induced myalgia is common.

Scoliosis and respiratory problems are mild or absent.

Antenatal form with arthrogryposis multiplex congenita (10% cases)

This diagnosis may be suspected prenatally with reduced fetal movements and polyhydramnios. This typically presents with contractures at birth due to poor foetal movement.

Other features include a long head, low set ears and a short neck.

The respiratory muscles can be moderately to severely affected and problems with breathing are common.

Genetics


The most common causes are mutations in the RYR1 and SEPN1 genes. In these cases the inheritance is autosomal recessive. Less common recessive mutations causing this condition include those in the TTN, MEGF10 and CACNA1S genes. Automsomal dominant mutations associated with this disease include those in MYH7 and CACNA1S.[citation needed]

The pathogenesis is not well understood at present.[citation needed]

Diagnosis


The diagnosis may be suspected on clinical grounds.

On blood testing the creatinine kinase may be raised.

Imaging with ultrasound or MRI will show abnormalities in the affected muscles but these changes are not diagnostic.

The diagnostic test is a muscle biopsy.

On biopsy type 1 fibres predominate. The sarcomeres are disorganised and the mitochondria depleted. Necrosis and fibrosis are absent. Within the fibres multiple cores are visible.

Differential diagnosis

Management


There is presently no curative treatment. Management is supportive.[citation needed]

There is an association with malignant hyperthermia and this should be borne in mind if anesthesia is required.[citation needed]

Epidemiology


The epidemiology of this condition is not known. Studies have suggested that the prevalence of all congenital myopathies lies between 35-50 per million children.[1][2]

History


This condition was first described in 1971.[3]

References


  1. ^ Hughes MI, Hicks EM, Nevin NC, Patterson VH (1996) The prevalence of inherited neuromuscular disease in Northern Ireland. Neuromuscul Disord 6:69–73
  2. ^ Darin N, Tulinius M (2000) Neuromuscular disorders in childhood: a descriptive epidemiological study from Western Sweden. Neuromuscul Disord 10:1–9
  3. ^ Engel AG, Gomez MR, Groover RV (1971) Multicore disease. Mayo Clin Proc 10:666–681







Categories: Rare syndromes | Syndromes affecting the heart




Information as of: 22.06.2021 10:33:17 CEST

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